Achievement
Original article
- Effects of the adenosine A(1) receptor agonist N(6)-cyclopentyladenosine
on phencyclidine-induced behavior and expression of the immediate-early
genes in the discrete brain regions of rats. Brain research. Molecular
brain research、Elsevier Science Publishers, 100(1-2), pp1-12、2002 Apr 30
Gotoh L, Kawanami N, Nakahara T, Hondo H, Motomura K, Ohta E, Kanchiku
I, Kuroki T, Hirano M, Uchimura H.
- In this study, we investigated the effect of adenosine A1 receptor neurotransmitter agonist N (6) -cyclopentyladenosine on acute-administered PCP, a model animal for schizophrenia. Changes in spontaneous behavior and IEG expressions in the local brain by PCP were suppressed by administration of CPA. It was suggested that the adenosine neurotransmission system may be involved in the pathology of schizophrenia.
- Association analysis of adenosine A1 receptor gene (ADORA1) polymorphisms with schizophrenia in a Japanese population. Psychiatr Genet. 2009 Dec;19(6):328-35. Gotoh L, Mitsuyasu H, Kobayashi Y, Oribe N, Takata A, Ninomiya H, Stanton VP Jr, Springett GM, Kawasaki H, Kanba S.
- In this study, I compared SNPs of the adenosine A1 receptor gene in Japanese schizophrenia patients and healthy controls and analyzed correlation. We found genetic polymorphisms correlated with schizophrenia.
- GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease. Leo Gotoh, Ken Inoue, Guy Helman, Sara Mora, Kiran Maski, Janet S Soul, Miriam Bloom, Sarah H Evans, Yu-Ichi Goto, Ljubica Caldovic, Grace M Hobson, Adeline Vanderver Molecular Genetics and Metabolism 12/2013
- In cell biological method, I investigated the effect of the SNP in the promoter region of GJC2 (Cx47) gene identified in the patients of PMLD on pathology.
- Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats. Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M. Behav Brain Res. 2016 Dec 1;323:11-14 doi: 10.1016/j.bbr.2016.11.008. [Epub ahead of print]
- This study is a psychopharmacological study using depression model animals, olfactory bulbectomized rats. It is suggested that administration of KNT-127, a δ opioid receptor agonist, recovers behavioral abnormalities exhibited by olfactory bulbectomized rats without causing weight loss, suggesting that δ opioid receptor stimulants are targets for novel antidepressants.
International Conference
- Stimulation of adenosine A1 receptor prevents phencyclidine-induced immediate-early
gene expression in rat brain L. GOTOH, T. NAKAHARA, H. HONDOH, K. MOTOMURA,
I. KANCHIKU, K. HASHIMOTO, T. TSUTSUMI, M. HIRANO, H. UCHIMURA, 2001 Collegium
Internationale Neuro-Psychophalmacologicum (CINP) Regional Meeting Hirosima,
Japan, 2001.
- Association analysis of adenosine A1, A2A, A2B, dopamine D1, and D2 receptor
genes with schizophrenia in the Japanese population. L. GOTOH, H. MITSUYASU,
H. KAWASAKI, Y. KOBAYASHI, N. MAEDA, S. KANBA American Society of Human
Genetics 2005 annual meeting、Salt Lake City, Utah, USA, Oct 25-29(28),
2005.
- Association Analysis of Adenosine A1 receptor (ADORA1) and Dopamine D1
receptor (DRD1) genes with schizophrenia in the Japanese population. L.
Gotoh, H. Kawasaki, H. Mitsuyasu, Y. Kobayashi, N. Oribe, A. Takata, S.
Kanba American Society of Human Genetics 2007 annual meeting, San Diego,
California, USA, Oct 23-27(25), 2007.
- Association Analysis of Adenosine A1 receptor (ADORA1) and Dopamine D1
receptor (DRD1) genes with schizophrenia in the Japanese population. L.
Gotoh, H. Mitsuyasu, A. Takata, Y. Kobayashi, K. Yamada, T. Yoshikawa,
H. Kawasaki, S. Kanba American Society of Human Genetics 2009 annual meeting,
Honolulu, Hawaii, USA、Oct 20-24 (22) , 2009.
- Association study of TCI scale and genetic variants of DRD4, DAT1 and 5HTT
with bipolar disorder in the Japanese. American Society of Human Genetics
2010 annual meeting L. Gotoh, N. Oribe, A. Takata, H. Mitsuyasu, H. Kawasaki,
S. Kanba Washington, DC, USA、Nov 2-6 (3) , 2010.
Conference in Japan
- The possibility of lysophosphatidic acid as biomarker of depression, The 13th Annual Meeting of the Japanese Society of Mood Disorder. Aug 16, 2016. Nagoya
This work was supported by JSPS KAKENHI Grant Number JP15K19758.
- The possibility of lysophosphatidic acid as biomarker of depression, The 35th Social Meeting of Pharmacological and biochemical studies on bipolar disorder. Nov 5, 2016. Yamaguchi
This work was supported by JSPS KAKENHI Grant Number JP15K19758.
Grant
April 2016 ~ March 2017
JSPS KAKENHI Grant Number (15K19758)
Quantitative analysis of lysophosphatidic acid in serum and cerebrospinal fluid of depressed patients
